The frontal lobe role in memory: a review of convergent evidence and implications for the Wada memory test.

Functional imaging studies have implicated the frontal lobe in many of the memory processes often thought to be the domain of medial temporal structures. Results from fMRI studies of normal subjects have suggested that some components of memory formation, including those components tested during the Wada memory test, may involve frontal lobe regions. Specific behavioral disruptions during carotid amytal injections support a model for frontal lobe anesthesia in explaining results of the Wada memory test. Cortical stimulation data suggest that frontal lobe disruption is sufficient to cause memory disturbances. The convergence of evidence suggests frontal lobe memory may limit the predictive value of the Wada memory test in defining the risk of memory loss following temporal lobectomy.